이상은
이상은 생명과학부/조교수
전공신경생리학, 신경면역학
연락처
031-881-7151
sangeun@cha.ac.kr
학력
- 2008-2013, 고려대학교 생명과학대학 생명과학부 이학사
- 2013-2019, 서울대학교 의과대학 의과학과 의학박사
경력
- 2020-2023, 박사후연구원, University College London, 영국
- 2023-2025, 서울대학교 의과대학 의학연구원 연구조교수
- 2025-현재, 차의과학대학교 생명과학부 조교수
논문
- [연구분야]
- Microglia-neuron interaction and synaptic dysfunctions in Neurodegenerative Diseases
- 신경세포와 미세아교세포 간의 상호작용이 시냅스 기능에 어떤 영향을 미치는지를 중심으로, 신경퇴행성 질환의 병태생리를 이해하고자 함.
- Genetic modulation
- Visualization of cellular interaction using live-cell imaging with 2D/3D/4D tracking platform
- . Multi-dimensional researches using Biomedical imaging
- Neuron-glia세포 간의 복잡한 상호작용을 시공간적·기능적으로 해석하기 위해, 다양한 바이오이미징 기법을 접목한 다차원적 연구를 수행함.
- Optophysiology – Endo/Exocytosis assay, Calcium assay
- Spatial / genetical manipulations in cellular level
- Super-resolution imaging
- 3D/4D IMARIS rendering
- 3. Biological and mathematical disease modeling for precision medicine
- 신경계 질환의 복잡한 병리기전을 정밀하게 규명하고, 환자 맞춤형 치료 전략을 제시하기 위해 생물학적 및 수학적 모델링을 결합한 연구를 수행함.
- Spatially-resolved transcriptomic analysis for disease-specific immune-cell profiling
- singla-cell RNA sequencing in iPSC-derived brain organoids
[국외논문]
2025- 25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer's disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition. Journal of Neuroinflammation
- cryo-EM structure of the heteromeric trpc1/c4 channel. Nature structural&Molecular Biology
2024- Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease. FEBS Openbio
- Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. ADVANCED SCIENCE.
- FGFR3 drives Aβ-induced tau uptake. Experimental and Molecular Medicine
- nArgBP2 together with GKAP and SHANK3 forms a dynamic layered structure. Frontiers in Cellular Neuroscience.
2023- Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. EMBO Journal
- Formation of aggresomes with hydrogel-like characteristics by proteasome inhibition. BBA -Gene Regulatory Mechanisms
- Biomolecular condensate assembly of nArgBP2 tunes its functionality to manifest the structural plasticity of dendritic spines. Experimental and Molecular Medicine
- An Alternative Splicing Variant of the Mixed-Lineage Leukemia 5 Protein Is a Cellular Adhesion Receptor for ScaA of Orientia tsutsugamushi. mBio
2021- SGIP1α, but Not SGIP1, is an Ortholog of FCHo Proteins and Functions as an Endocytic Regulator. Frontiers in Cell and Developmental Biology
- DXplorer: A Unified Visualization Framework for Interactive Dendritic Spine Analysis using 3D Morphological Features. IEEE Transactions on Visualization and Computer Graphics
- Multivalent electrostatic pi-cation interaction between synaptophysin and synapsin is responsible for the coacervation. Molecular Brain
- SCAMP5 plays a critical role in axonal trafficking and synaptic localization of NHE6 to adjust quantal size at glutamatergic synapses. Proceedings of the National Academy of Sciences
- Cooperative function of Synaptophysin and Synapsin in the generation synaptic vesicle-like clusters in non-neuronal cells. Nature Communications
2020- CycleGAN with a Blur Kernel for Deconvolution Microscopy: Optimal Transport Geometry. IEEE Transactions on Computational Imaging
2019- SGIP1α functions as a selective endocytic adaptor for the internalization of synaptotagmin 1 at synapses. Molecular Brain
2018- nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders. Experimental and Molecular Medicine
- Cografting astrocytes improves cell therapeutic outcomes in a Parkinson's disease model. Journal of Clinical Investigation
2016- nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders. BMB Reports
- nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Proceedings of the National Academy of Sciences
- ADP-ribosylation factor 6 (ARF6) bidirectionally regulates dendritic spine formation depending on neuronal maturation and activity. Journal of Biological Chemistry
- SCAMP5 plays a critical role in synaptic vesicle endocytosis during high neuronal activity. Journal of Neuroscience