Dongyeon Hwang

Dongyeon Hwang Professor

전공Stem Cell, Neuronal Regeneration
연락처 031-881-7142 hdy@cha.ac.kr

학력

  • 학사: 서울대학교 자연과학대학 미생물학과
  • 석사: 서울대학교 자연과학대학 미생물학과
  • 박사: University of Pittsburgh, School of Medicine (피츠버그대학교 의과대학 (분자유전학, 유전자치료학 전공)

경력

  • Research Associate, 유전공학센터 (KIST), 현 생명공학연구원
  • 조교, University of Pittsburgh, School of Medicine
  • 박사후 연구원 (Postdoctoral fellow), 하버드 의대 (Harvard Medical School)
  • 전임강사 (Instructor), 하버드 의대 (Harvard Medical School)
  • 조교수, Assistant Professor (정년트랙), 하버드 의대 (Harvard Medical School)
  • 부교수, Associatet Professor, 차의과학대학교
  • 교수, Professor, 차의과학 대학교


  • [대외활동]
  • 2000 – Present Society for Neuroscience (SFN) – Member (ID: 100003685)
  • 2001 – Present American Society of Gene Therapy (ASGT) – Member (ID: 6945)
  • 2008 – Present International Society for Stem Cell Research (ISSCR) – Member (ID: 20230)
  • 2010 – Present 한국 유전자세포치료학회 – 기획분과 및 학술분과 위원
  • 2011 – Present Tissue Engineering and Regenerative Medicine (TERM) (SCIE), Associate Editor
  • 2012 – 2014 한국 줄기세포학회 이사
  • 2012 – Present 한국 조직공학 - 재생의학회, 학술위원, 줄기세포분과 위원장
  • 2013.10.1 – 2014.10.31 2014 세계 조직공학Ÿ재생의학회 아태대회 (TERMIS-AP) 조직위원회.
  • 2014.10.10-11 한국 유전자세포치료학회 주최 국제학술대회, 줄기세포세션 오거나이저
  • 2015 – Present (사단법인) 한국 줄기세포학회 대의원 (이전의 “이사”에 해당)
  • 2015 – Present 한국 조직공학 - 재생의학회, 교육위원장/교육이사


  • [수상]
  • 2002 Alfred Pope Young Investigator Award (전 세계적으로 신경과학계의 미래 유망한 과학자에게 주는 상)
  • 2004 NARSAD Young Investigator Award (미국 내의 신경/정신과학 분야의 촉망 받는 젊은 연구자에게 2년간의 연구비와 함께 주는 권위 있는 상)
  • 2005. 12. 15 Partners in Excellence Award (하버드 의대와 소속병원들에 속한 연구자들 중에 큰 공헌을 한 연구자에게 수여되는 상)
  • 2011. 01. 23 최우수 발표상 (제3회 의과학자육성지원 공동교육 워크숍)
  • 2011. 09 – 현재 Who’s Who in America 2012 (66th Edition)
  • 2011. 11. 25 최우수 포스터 상 (제5차 한국유전자세포치료학회)
  • 2012. 01. 28 최우수 발표상 (제4회 의과학자육성지원 공동교육 워크숍)
  • 2012. 08. 31 우수포스터상 (제8회 한국줄기세포학회 학술대회)
  • 2012. 11. 23 우수포스터상 (제6차 한국유전자세포치료학회) – 2013. 1. 24
  • 2013. 5. 30 우수포스터상 (제15차 한국조직공학재생의학회 정기학술대회)
  • 2013. 8. 29 메디포스트 우수논문상 (제15차 한국 조직공학 재생의학회 정기학술대회)
  • 2014. 9. 27 메디포스트 우수논문상 (제15차 한국 조직공학 재생의학회 정기학술대회)
  • 2014 – 현재 Marquis who’s who in the world
  • 2016 – 현재 Who’s Who in Science and Engineering
  • 2017.12.27 2018 Albert Nelson Marquis Lifetime Achievement Award
  • 2019. 1. 9 The 2019 Winter Conference of the korean Society for Stem Cell Research, KSSCR Best Poster Award

논문

    [연구분야]
    줄기세포학
  • 임상용 역분화줄기세포 (iPS cells) 제작/교차분화/Direct conversion
  • 신경계세포분화,순수분리, 및 장기배양 연구
  • 줄기세포의 신경분화 기작 연구
  • 성체줄기세포를이용한치료제 개발 연구
  • 뇌오가노이드(미니뇌)를이용한 악성뇌종양 치료제 개발 연구
  • HLA 유전자교정을통한타가면역적합 세포치료제 제작기술 연구

  • 신경재생학
  • 중추신경계 질환 – 뇌졸중, 파킨슨병, 치매
  • 말초신경계 질환


  • [논문]
    최근 5년간: 2011-현재 (*: Corresponding author)
  • Trophoblast glycoprotein is a novel marker for sorting of ventral mesencephalic dopaminergic precursors derived from human pluripotent stem cells, Yoo J-E, Lee DR, Park S, Ahn J-B, Shin H-R, Lee KG, Kim D-S, Jo M-Y, Eom J-H, Cho MS, Hwang D-Y*, Kim D-W*, npg Parkinson’s Disease, volume 7, Article number: 61 (2021). Published: 19 July 2021 (*Corresponding author)
  • Fine-tuning of dual SMAD inhibition to differentiate human pluripotent stem cells into neural crest stem cells, Kim H-M, Noh HB, Lee S-H, Lee G-G, Chang B, Cheong E, Lee CJ, Hwang D-Y*, Cell Proliferation, in press. (*Corresponding author)
  • Functional recovery by colon organoid transplantation in a mouse model of radiation proctitis, Jee J, Park J-H, Im JH, Kim MS, Park E, Lime T, Choi WH, Kim JH, Kim WR, Ko JS, Jeong SY, Ko SY, Lee JI, Lee KJ, Jeon H, Seo J-W, Hwang DY, Shin HS, Yoo J*, Biomaterials, May 29;275:120925.
  • Off-the-shelf, immune-compatible human embryonic stem cells generated via CRISPR mediated genome editing, Kim A, Lee K-G, Kwon Y, Lee K-I, Yang H-M, Habib O, Kim J, Kim S-T, Kim SJ, Kim J-S, and Hwang D-Y*, 09 January 2021, Stem Cells Reviews and Reports, doi: 10.1007/s12015-020-10113-7
  • The EGFRvIII mutation frequently found in gliomas induces astrogenesis in human cerebral organoids, Kim H-M, Lee S-H, Lim J, Yoo J, and Hwang D-Y*, Cell Proliferation, 2020 Dec 6; e12965. doi: 10.1111/cpr.12965
  • Human umbilical cord-derived mesenchymal stem cells alleviate schizophrenia-relevant behaviors in amphetamine-sensitized mice by inhibiting neuroinflammation, You M-J, Park H-S, Yang B, Jang KB, Yoo J, Hwang D-Y, Kim MY, Kim B, Lee S-H, and Kwon M, Translational Psychiatry, 2020 Apr 27;10(1):123. doi: 10.1038/s41398-020-0802-1
  • Lee SY, Noh HB, Kim HT, Lee KI, and Hwang D-Y*, Glis family proteins are differentially implicated in the cellular reprogramming of human somatic cells, 2017, Oncotarget, Published Online: August 18, 2017, DOI: https://doi.org/10.18632/oncotarget.20334.
  • Jang J, Huh YJ, Cho H-J, Lee Boram, Park JP, Hwang D-Y*, and Kim D-W*, SIRT1 enhances the survival of human embryonic stem cells by promoting DNA repair, Stem Cell Reports, 2017, Aug., 8, 9:1-13, DOI: http://dx.doi.org/ 10.1016/j.stemcr.2017.06.001.
  • Yoo J, Kim H-S, Seo J-J, Eom J-H, Choi S-M, Park S, Kim D-W*, and Hwang D-Y*, Therapeutic effects of umbilical cord blood plasma in a rat model of acute ischemic stroke, Oncotarget, 2016 Nov 29; 7(48):79131-79140. doi: 10.18632/oncotarget.12998.
  • Lee K-I, Lee S-Y, and Hwang D-Y, Extracellular matrix-dependent generation of integration- and xeno-free iPS cells using a modified mRNA method, Stem Cells International, 2016, 216:1-11.
  • Oh J, Lee K-I, Kim H-T, You Y, Yoon D-H, Song KY, Cheong E, Ha Y, and Hwang D-Y*, Human induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury, Stem Cell Research & Therapy, 2015, 6(1):125.
  • Kim J, Jang YJ, An SY, Son JS, Lee J, Lee G, Park JY, Park H-J, Hwang D-Y, Kim J-H, and Han J, Enhanced metabolizing activity of human ES cell-derived hepatocytes using a 3D culture system with repeated exposures to xenobiotics, Toxicological Sciences, 2015 Sep, 147(1):190-206.
  • Lee D. R., Yoo J-E, Lee J, Park S LeeJ, Park C-Y, Ji E, Kim H-S, Hwang D-Y, Kim D-S, and Kim D-W, PSA-NCAM-Negative Neural Crest Cells Emerging during Neural Induction of Pluripotent Stem Cells Cause Mesodermal Tumors and Unwanted Grafts, Stem Cell Reports, May 12, 2015, 4:821-834.
  • Yoo J, Seo JJ, Eom J-H, and Hwang D-Y*, Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke, Cell Transplantation, Feb. 2015, 24(2):167-82.
  • Lee K-I, Kim H-T, and Hwang D-Y*, Footprint- and xeno-free human iPSCs derived from urine cells using extracellular matrix-based culture conditions, Biomaterials, September, 2014, 35 (29):8330-8338. ISSN: 0142-9612.
  • Hyeong-Taek Kim, Kang-In Lee, Dong-Wook Kim, and Dong-Youn Hwang*, An ECM-based culture system for the generation and maintenance of xeno-free human iPS cells, Biomaterials, Jan. 2013, 34(4):1041-50.
  • Jongman Yoo, Hansoo Kim, and Dong-Youn Hwang*, Stem cells as promising therapeutic options for neurological disorders. J of Cellular Biochemistry, Apr. 2013, 114(4):743-53.
  • Dong-Geol Lee, Dong-Moon Im, HeeCheol Kang, Pyeong Yun, Sun-Ki Park, Seung-Su Hyun, and Dong-Youn Hwang*, Pseudogulbenkiania gefcensis sp. nov., isolated from soil samples, Int J Syst Evol Microbiol, Jan. 2013, 63 (Pt 1):187-91.
  • Jee J, Jeon H, Hwang D*, Sommer P, Park Z, Cechetto J, Dorval T*., High Content Screening for Compounds that Induce Early Stages of Human Embryonic Stem Cell Differentiation Stem cells as promising therapeutic options for neurological disorders. Comb Chem High Throughput Screen, Sep. 2012, 15(8):656-665.
  • Jang J, Yoo JE, Lee JA, Lee DR, Kim JY, Huh YJ, Kim DS, Park CY, Hwang DY, Kim HS, Kang HC, Kim DW. Disease-specific induced pluripotent stem cells: a platform for human disease modeling and drug discovery. Experimental and Molecular Medicine. Mar. 2012, 44:202-13.
  • Yoo J, Seo J-J, Eom J-H, Hwang D-Y*. Effects of SDF1 delivered at different phases of transient focal ischemia in rats, Neuroscience, May 3, 2012, 209:171-186.
  • Kim H-T, Lee K-I, Hwang D-Y*. The feeder-free culture of human embryonic stem cells and induced pluripotent stem cells in the presence of histone deacetylase inhibitors. Tissue Engineering and Regenerative Medicine, Feb, 2012, 9(suppl.1):55-64.
  • Jang J, Kang HC, Kim HS, Kim JY, Huh YJ, Kim DS, Yoo JE, Lee JA, Lim B, Lee J, Yoon TM, Park IH, Hwang D-Y, Daley GQ, Kim DW. Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients, Ann Neurol. Sep. 2011, 70:402-9.
  • Eun-Sil Lee, Song-Hee Yu, Yu-Jin Jang, Dong-Youn Hwang, and Chang-Jin Jeon, Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells into the Developing Mouse Eye, Acta Histochem. Cytochem., Oct., 2011, 44:213-21.
  • Lee K.-I., Jeon J., Lim D., Hwang D.-Y.*, Characterization of the cord blood-derived CD34+ cell fractions during ex vivo suspension culture, Tissue Engineering and Regenerative Medicine, 2011, 8(suppl.1):44-50.
  • Chang B., Kim H.-T., Jee J.-H., Yoon T.-M., Hwang D.-Y.*, Culture of human embryonic stem cells using sodium butyrate (NaB), a histone deacetylase inhibitor, Tissue Engineering and Regenerative Medicine, 2011, 8(suppl.1):51-58.

저서/역서/편서

    최근 5년간: 2011-현재
  • Dong-Youn Hwang, “Chapter 1. Feeder-Free Growth of Undifferentiated Human Embryonic Stem Cells” in the book of Human Embryonic and Induced Pluripotent Stem Cells, Ye, Kaiming, & Jin, Sha (Eds), Sep. 7, 2011, 1st Edition, Humana Press, ISBN-10: 1617792667 | ISBN-13: 978-1-61779-266-3 | Edition: 2012,
    [http://www.springer.com/life+sciences/cell+biology/book/ 978-1-61779-266-3]
  • 김형택 & 황동연. “제I장. 줄기세포의 생성” in the book of 재생의학 (Regenerative Medicine), 유진, 이일우, & 김문석 (Eds), 제4판, 군자출판사, 2017년 출간 예정


  • [특허]
    국제특허
  • 국제 개별국가 진입: 미국, 일본, 유럽, 중국
    발명: IMMUNE-COMPATIBLE CELLS CREATED BY NUCLEASE-MEDIATED EDITING OF GENES ENCODING HLA
    PCT출원번호: PCT/KR2015/008267)
    개별국가진입 일자: 2017. 2월

  • 국내특허
  • 2 종 이상의 역분화 유도 인자를 코딩하는 유전자를 포함하는 유전자 구조체및 이를 이용한 역분화 만능 줄기세포의 제조방법 (출원일: 2008.07.24, 등록번호: 10-0988289, 등록일: 2010.10.11)
  • 역분화 유도 인자를 포함하는 헤르페스 심플렉스 앰플리콘 바이러스를 이용한 역분화 전분화성 줄기 세포의 제조방법 (출원일: 2008.07.24, 등록번호: 10-1061541, 등록일: 2011.08.26)
  • 2 종 이상의 표적 유전자를 동시에 함유하는 바이러스의 제조방법 (출원일: 2008.07.24, 등록번호: 10-1055305, 등록일: 2011.08.02)
  • 줄기세포 배양용 조성물과 줄기세포 배양방법 (출원일: 2009.12.23, 등록번호: 10-1249801, 등록일: 2013.03.27)
  • 줄기세포성 유지 또는 줄기세포 분화를 위한 줄기세포 배양용 조성물 (출원일: 2010.01.19, 등록번호: 10-1133553, 등록일: 2012.03.29)
  • 인간 배아줄기세포 또는 역분화 만능줄기세포의 줄기세포성 유지용 배지 및 이를 이용한 배양 방법 (출원일: 2011.04.26, 등록번호: 10-1313535, 등록일: 2013.09.25)
  • 무세포 제대혈을 유효성분으로 포함하는 뇌손상의 예방 또는 치료용 약학 조성물 (출원일: 2013.04.02, 등록번호: 10-1460504, 등록일: 2014.11.05)
  • 줄기 세포의 신경 전구 세포로의 분화용 조성물 및 이를 이용한 방법 (출원일: 2014.10.16, 등록번호: 10-1613677, 등록일: 2016.04.04)
  • 줄기 세포의 신경 전구 세포로의 분화용 조성물 및 이를 이용한 방법 (출원일: 2014.10.16, 등록번호: 10-1660450, 등록일: 2016.09.21)

  • [기술이전]
  • 10.22 선급+마일스톤 기반 기술